Type 1 Diabetes

A First in Class Product that can act as a “Platform” Applicable to Multiple Diseases

Type 1 Diabetes

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  • Significant cause of morbidity and mortality Top causes of blindness, significant contributory to heart failure, kidney failure, and other secondary complications
  • Transplantation only cure
  • Immunologically mediated
  • Control of immunity/re-establishment of tolerance could allow for stopping disease in honeymoon period, or also increasing efficacy of transplants
  • Transplants are effective but you need 3-4 donors per recipient because they do not fix the underlying problem immune dysregulation.

ImmCelz® Treatment Reduces Diabetes

Female non obese diabetic (NOD) mice where induced to undergo hyperaccelerated diabetes by administration of streptozotocin (STZ). Mice (10 per group) were untreated, treated with STZ, treated with STZ + untrained T cells or STZ + trained T cells (ImmCelz®). Diabetes onset was determined by blood glucose levels.
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ImmCelz® Enhances Production of
Regenerative Cytokines: EGF

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ImmCelz® Enhances Production of
Regenerative Cytokines: IGF

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ImmCelz® Enhances Production of
Regenerative Cytokines: HGF

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ImmCelz® Increases Efficacy of Tolerogenic
Therapies: BCG

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ImmCelz® Increases Efficacy of Tolerogenic
Therapies: GM-CSF

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