A First in Class Product that can act as a “Platform” Applicable to Multiple Diseases
Type 1 Diabetes
Significant cause of morbidity and mortality Top causes of blindness, significant contributory to heart failure, kidney failure, and other secondary complications
Transplantation only cure
Immunologically mediated
Control of immunity/re-establishment of tolerance could allow for stopping disease in honeymoon period, or also increasing efficacy of transplants
Transplants are effective but you need 3-4 donors per recipient because they do not fix the underlying problem immune dysregulation.
ImmCelz® Treatment Reduces Diabetes
Female non obese diabetic (NOD) mice where induced to undergo hyperaccelerated diabetes by administration of streptozotocin (STZ). Mice (10 per group) were untreated, treated with STZ, treated with STZ + untrained T cells or STZ + trained T cells (ImmCelz®). Diabetes onset was determined by blood glucose levels.
ImmCelz® Enhances Production of Regenerative Cytokines: EGF
ImmCelz® Enhances Production of Regenerative Cytokines: IGF
ImmCelz® Enhances Production of Regenerative Cytokines: HGF
ImmCelz® Increases Efficacy of Tolerogenic Therapies: BCG
ImmCelz® Increases Efficacy of Tolerogenic Therapies: GM-CSF
