A First in Class Product that can act as a “Platform” Applicable to Multiple Diseases
In Order to Understand ImmCelz® We Need to know how Stem Cells Work
Original concept was that stem cells home to area of injury and repopulate tissue
Clinical studies showed very little stem cell engraftment into injured organs
Secondary concept was that stem cells produce exosomes and tissue growth factors that activate endogenous cells
Our concept is that stem cells reprogram immune cells and immune cells mediate regenerative and anti-inflammatory
Support for Our Concept the Stem Cells Work by Immune Modulation/T regulatory Cells
When stem cells are injected, they primarily get stuck in the lung due to size…this means they do not always home to target organ
Injection of stem cells in anatomically distinct places still evokes therapeutic response. For example, injecting stem cells in calf muscle is protective against heart attack.
T regulatory cells are anti-inflammatory and angiogenic.
T regulatory cells are generated by stem cells in vitro and in vivo
In many studies depletion of T regulatory cells results in abrogation of stem cell therapeutic activity
